Chromatophagy: Autophagy goes nuclear and captures broken chromatin during arginine-starvation

نویسندگان

  • Hsing-Jien Kung
  • Chun A Changou
  • Chien-Feng Li
  • David K Ann
چکیده

Hsing-Jien Kung,1,2,3,4,*,y Chun A Changou,2,3,y Chien-Feng Li, and David K Ann Department of Biochemistry &Molecular Medicine; UC Davis Comprehensive Cancer Center; Sacramento, CA USA; Integrated Laboratory; Center of Translational Medicine; Taipei Medical University; Taipei, Taiwan, Republic of China; Graduate Institute of Translational Medicine; Taipei Medical University; Taipei, Taiwan, Republic of China; National Health Research Institutes; Taiwan; Republic of China; Department of Pathology; Chi-Mei Medical Center; Tainan, Taiwan, Republic of China; National Institute of Cancer Research; National Health Research Institutes; Tainan, Taiwan, Republic of China; Department of Biotechnology; Southern Taiwan University of Science and Technology; Tainan, Taiwan, Republic of China; Department of Metabolic Disorders Research; Beckman Research Institute; City of

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.

Autophagy is the principal catabolic prosurvival pathway during nutritional starvation. However, excessive autophagy could be cytotoxic, contributing to cell death, but its mechanism remains elusive. Arginine starvation has emerged as a potential therapy for several types of cancers, owing to their tumor-selective deficiency of the arginine metabolism. We demonstrated here that arginine depleti...

متن کامل

Arginine deprivation and autophagic cell death in cancer.

Our increasing awareness over the last decade, that reprogramming of cellular energetics is a key hallmark of tumorigenesis, has reinvigorated the search for novel tractable metabolic targets in cancer cells (1). From innovative diagnostics based on the tracer 18F-deoxyglucose in positron emission tomography (FDG-PET) to the development of next-generation antimetabolites built on L-asparaginase...

متن کامل

Knockdown of mitofilin inhibits autophagy and facilitates starvation-induced apoptosis in HeLa cells

Objective(s): Mitofilin contributes to the maintenance of mitochondrial structure and functions. This study was undertaken to determine the mechanisms underlying its regulation of apoptosis.  Materials and Methods: Mitofilin was knockdowned by specific short hairpin RNA (shRNA) and the stable HeLa cell clone was selected. The autophagy a...

متن کامل

Buffering roles of (pro)renin receptor in starvation‐induced autophagy of skeletal muscles

Autophagy is an intracellular catabolic process contributing to the regulation of nutrient homeostasis and cellular remodeling. Studies revealed that the nuclear translocation of transcription factor EB (TFEB) plays a key role in lysosomal biogenesis and autophagic pathways. The (pro)renin receptor [(P)RR] is a multifunctional protein playing a pivotal role in regulation of the tissue renin-ang...

متن کامل

Endogenous HMGB1 regulates autophagy

Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stimuli t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2015